MGF (Mechano Growth Factor)

Mechano Growth Factor (MGF) with sequence YQPPSTNKNTKSQRRKGSTFEEHK-NH2, is a novel splice variant of the insulin growth factor -1 (IGF-1), also known as IGF-1Ec in humans and IGF-1Eb in rodents. Studies have suggested that MGF plays a number of physiological roles because the failure in its expression may result to age-related loss of skeletal function. One included in its functions is its ability to become a potent neuroprotective as supported by the study that has shown functional copies of the MGF cDNA to be expressed in a plasmid vector which then protected facial neurons after nerve damage. One such failure is called sarcopenia. The appearance of MGF also initiates the upregulation of new protein synthesis.




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