Melanotan II (MT 2)

Melanotan-II, a cyclic heptapeptide homologue of the endogenous melanocortin peptide α-melanocyte-stimulating hormone (α-MSH) with sequence Ac-Nle-cyclo[(beta-D)-H(d-F)RW-(epsilon-K)]-NH2, is a synthetic, non-selective melanocortin receptor agonist with high affinity for MC1R, 3R, 4R, and 5R. It is used to prevent a sunlight-induced skin cancer by stimulating the skin tanning process. Studies have shown that melanotan II can actually reduce the body weight and the adipose tissue in the viscera of the mice and suppresse the caloric intake of the organism, which has implications in clinical applications of the possible treatment to reduce carbohydrate or calorie intake especially for the overweight and the obese. Melanotan II can also actually increased sexual desire and even concluded that it is a potent initiator of penile erection in men especially with that of erectile dysfunction.




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