IGF-1 LR3 (Insulin-like Growth Factor)

IGF-1 LR3, also known as Long R3 Insulin-like Growth Factor-I with 83 amino acids, is a human recombinant, single, non-glycosylated analog of IGF-I with the substitution of an Arginine (Arg) for the Glutamic Acid (Glu) at position 3, as well as a 13 amino acid extension peptide. This sequence change causes IGF-1 to avoid binding to proteins and allow it to have a much longer half life, around 20-30 hours. Due to this, it has been suggested that IGF-1 LR3 is more potent than the IGF-1 in many aspects such as increasing amino acid transport to cells, increasing glucose transport, increasing protein synthesis, decreasing protein degradation and so on.




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